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Raman scattering technology can be used to analyze non-phosphor nanodiamonds. The worker used a laser to bombard the sample diamond. The laser can react with the chemical bond of the vibration, and the vibration frequency of these chemical bonds can be obtained by the scattered photons. However, traditional Raman scattering is relatively weak, and it takes a long time to form a clear image, which has certain drawbacks for living organisms. Scientists have successfully solved the problem of long imaging time by using two-beam incident infrared lasers using the Coherent Anti-Stokes-Raman Scattering (CARS) technique. At the same time as the frequency difference between the two infrared lasers and the vibration frequency of the chemical bond, all the same chemical bonds start to vibrate synchronously, which enhances the signal and shortens the imaging time. This technology is critical for nanodiamond medical devices, especially when a large number of identical carbon-carbon bonds are present. 
Professor Paola Borri of Cardiff University in the United Kingdom and colleagues used their own CARS microscope to perform imaging experiments on diamonds with a radius of 70-150 nm in water. From the obtained imaging data, CARS microscopy technology can observe a single nano-diamond with a minimum size of 27 nm. In fact, many medical nanodiamonds are much smaller, usually only 1-2 nanometers. Despite this, Professor Paola Borri has confidence in his CARS microscope.
When positioning a specific cell such as a cancer cell, the size of the nanoparticle should not be too small, otherwise it is easily overlooked. Paola Borri said: "Now, we can use CARS technology to link with nanodiamond quantitative measurement, and observe a single diamond particle. The in-situ direct measurement of nanodiamond in living cells is simply impossible with traditional phosphor technology. At present, researchers have successfully imaged nanodiamonds in human cells, and the whole process is zero-harm to the organism."
New CARS nanodiamond imaging technology
Abstract Recently, British scientists have successfully developed a new microscope technology for the observation of nanodiamonds in living cells; this technology will play an important role in medical research and clinical treatment. The cytotoxicity of nanodiamonds is very low, which makes it a medium for medical sensor imaging and drug delivery...
Recently, British scientists have successfully developed a new microscope technology for the observation of nanodiamonds in living cells; this technology will play an important role in medical research and clinical treatment. The low cytotoxicity of nanodiamonds makes it a vehicle for medical sensor imaging and a carrier for drug delivery. However, many medical devices are currently required to be applied to nano-diamond phosphors, such as nitrogen vacancy centers, which need to be developed under laser technology. The manufacturing process is complicated and the equipment is expensive.