1) Fluoxetine Hydrochloride Details

Product Name:Fluoxetine Hydrochloride
Synonyms:(+-)-methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanaminehydrochlorid;3-(p-trifluoromethylphenoxy)-n-methyl-3-phenylpropylaminehydrochloride;N-Methyl-3-[(4-trifluoroMethyl)phenoxy]-3-phenylpropylaMine HCl;(S)-N-Methyl-3-(4-trifluoroMethylphenoxy)-3-(phenyl-d5)propylaMine Hydrochloride;Affectine-d5
CAS:56296-78-7
MF:C17H19ClF3NO
MW:345.79
EINECS:260-101-2


2) Fluoxetine Hydrochloride Chemical Properties
Chemical Properties    White to Off-White Powder
Melting point  158-159°C
Fp   9ºC
Solubility  H2O: soluble (sparingly)
Color   white
Water Solubility   Soluble in dimethylsulfoxide and water.


3) Fluoxetine Hydrochloride Usage

Uses:A labelled selective serotonin reuptake inhibitor (SSRI). Used as an antidepressant.
Biological Activity: Selective serotonin reuptake inhibitor. Binds to the human 5-HT transporter with a K i of 0.9 nmol/l and is between 150- and 900- fold selective over 5-HT 1A , 5-HT 2A , H 1 , α 1 , α 2 -adrenergic, and muscarinic receptors. Antidepressant. Also available as part of the Serotonin Uptake Inhibitor Tocriset™ .


4) Antidepressants    

Fluoxetine hydrochloride is a selective serotonin reuptake inhibitor (SSRI),it is adapted to the treatment of various depressive disorders, including mild or major depression, bipolar disorder depression, psychogenic depression and depressive neurosis. The mechanism is inhibiting neuronal uptake of serotonin from the synaptic cleft, increasing this neurotransmitter in the gap for practical use , thereby improving the emotional state,and treating depressive disorders. Common adverse reactions are dry mouth, loss of appetite, nausea, insomnia, fatigue,  a few cases of anxiety and headaches are seen . Because fluoxetine hydrochloride has longer half-life, patients whose liver and kidney function are poor or elderly patients, should appropriately reduce the dose. Children should be applied in accordance with the doctor's advice. Patients who has the history of epilepsy, pregnancy or lactation women should use with caution . If rash or fever occurs, the drug should be discontinued immediately and symptomatic treatment should be given. It  is not appropriate to be used with monoamine oxidase inhibitor (MAOI) ; if necessary, the drug should be discontinued after five weeks, before switching to a monoamine oxidase inhibitor (MAOI).
 

1) Fluoxetine Hydrochloride Details

Product Name:Fluoxetine Hydrochloride
Synonyms:(+-)-methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanaminehydrochlorid;3-(p-trifluoromethylphenoxy)-n-methyl-3-phenylpropylaminehydrochloride;N-Methyl-3-[(4-trifluoroMethyl)phenoxy]-3-phenylpropylaMine HCl;(S)-N-Methyl-3-(4-trifluoroMethylphenoxy)-3-(phenyl-d5)propylaMine Hydrochloride;Affectine-d5
CAS:56296-78-7
MF:C17H19ClF3NO
MW:345.79
EINECS:260-101-2


2) Fluoxetine Hydrochloride Chemical Properties
Chemical Properties    White to Off-White Powder
Melting point  158-159°C
Fp   9ºC
Solubility  H2O: soluble (sparingly)
Color   white
Water Solubility   Soluble in dimethylsulfoxide and water.


3) Fluoxetine Hydrochloride Usage

Uses:A labelled selective serotonin reuptake inhibitor (SSRI). Used as an antidepressant.
Biological Activity: Selective serotonin reuptake inhibitor. Binds to the human 5-HT transporter with a K i of 0.9 nmol/l and is between 150- and 900- fold selective over 5-HT 1A , 5-HT 2A , H 1 , α 1 , α 2 -adrenergic, and muscarinic receptors. Antidepressant. Also available as part of the Serotonin Uptake Inhibitor Tocriset™ .


4) Antidepressants    

Fluoxetine hydrochloride is a selective serotonin reuptake inhibitor (SSRI),it is adapted to the treatment of various depressive disorders, including mild or major depression, bipolar disorder depression, psychogenic depression and depressive neurosis. The mechanism is inhibiting neuronal uptake of serotonin from the synaptic cleft, increasing this neurotransmitter in the gap for practical use , thereby improving the emotional state,and treating depressive disorders. Common adverse reactions are dry mouth, loss of appetite, nausea, insomnia, fatigue,  a few cases of anxiety and headaches are seen . Because fluoxetine hydrochloride has longer half-life, patients whose liver and kidney function are poor or elderly patients, should appropriately reduce the dose. Children should be applied in accordance with the doctor's advice. Patients who has the history of epilepsy, pregnancy or lactation women should use with caution . If rash or fever occurs, the drug should be discontinued immediately and symptomatic treatment should be given. It  is not appropriate to be used with monoamine oxidase inhibitor (MAOI) ; if necessary, the drug should be discontinued after five weeks, before switching to a monoamine oxidase inhibitor (MAOI).